Development of elastin-like polypeptide for targeted specific gene delivery in vivo (2020)
Sequence: Tat-(AP1)x4-ELP (VPGXG)x48
| Experiment Id | EXP000506 |
|---|---|
| Paper | Development of elastin-like polypeptide for targeted specific gene delivery in vivo |
| Peptide | Tat-A4V48 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | 50–200 nM |
| Mixing Ratio | 1:20 (siRNA:ELP) |
| Formulation Format | ELP–siRNA nanocomplex |
| Formulation Components | ELP ± Tat ± AP1 |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | 4T1-luc, MDA-MB231 |
| Animal Model | |
| Administration Route | |
| Output Type | luciferase knockdown |
| Output Value | |
| Output Units | |
| Output Notes | |
| Toxicity Notes | no significant cytotoxicity |
| Curation Notes |