Ac-E(Chol)E(Chol)-HHHHH-YGRKKRRQRRR
Sequence: Tat peptide core with variable His repeats and cholesterol–glutamate lipid (see Fig. 4A for exact composition)
| Experiment Id | EXP000588 |
|---|---|
| Paper | Lipid-modified cell-penetrating peptide-based self-assembly micelles for co-delivery of narciclasine |
| Peptide | Ac-E(Chol)E(Chol)-HHHHH-YGRKKRRQRRR |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | varied (micelle formulation) |
| Rna Concentration | ~50 nM (in vitro) |
| Mixing Ratio | N/P ≥10:1 |
| Formulation Format | Self-assembled lipid-modified CPP micelles |
| Formulation Components | Lipid-modified CPP + siULK1 ± narciclasine |
| Size Nm | 96.00 |
| Zeta Mv | 15.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HepG2; Huh-7; Bel-7402 |
| Animal Model | |
| Administration Route | |
| Output Type | Cellular uptake screening |
| Output Value | Screened; not advanced to in vivo studies |
| Output Units | |
| Output Notes | Screening variant shown in Fig. 4A; not selected for further development |
| Toxicity Notes | |
| Curation Notes |