Sequence: RRRRRRRRRFFC
| Experiment Id | EXP000594 |
|---|---|
| Paper | Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leuko |
| Peptide | R9F2 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | 0.5–5 μM (as P-PMO) |
| Rna Concentration | Equimolar to peptide (conjugate) |
| Mixing Ratio | 1:1 (covalent conjugate) |
| Formulation Format | Peptide–PMO conjugate (P-PMO) |
| Formulation Components | CPP covalently linked to PMO |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | Primary murine splenocytes, macrophages, dendritic cells |
| Animal Model | |
| Administration Route | |
| Output Type | Antisense activity; splice redirection; protein knockdown |
| Output Value | Robust splice redirection and knockdown only for (RXR)4 |
| Output Units | |
| Output Notes | (RXR)4 uniquely enabled nuclear delivery and functional antisense activity |
| Toxicity Notes | Low toxicity up to 5 μM |
| Curation Notes |