Sequence: (D-Arg)8
| Experiment Id | EXP000606 |
|---|---|
| Paper | Cooperative Cellular Uptake and Activity of Octaarginine Antisense Peptide Nucleic Acid (PNA) Conjug |
| Peptide | r8-PNA |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | 0.125–5 µM |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | self-assembled nanoparticles (serum) |
| Formulation Components | r8-PNA |
| Size Nm | 100.00 |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HeLa pLuc/705; PC-3; p53R |
| Animal Model | |
| Administration Route | |
| Output Type | splice correction / luciferase induction |
| Output Value | dose dependent |
| Output Units | |
| Output Notes | Cooperative uptake in serum; nanoparticle formation |
| Toxicity Notes | Low toxicity |
| Curation Notes |