Tumor suppressor protein-inspired peptide for siRNA delivery and synergistic cancer therapy (2025)
Sequence: CPP44-p16MIS-4R (CPP44RPM)
| Experiment Id | EXP000623 |
|---|---|
| Paper | Tumor suppressor protein-inspired peptide for siRNA delivery and synergistic cancer therapy |
| Peptide | CPP44 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | siRNA dose 1 mg/kg |
| Rna Concentration | 1 mg/kg |
| Mixing Ratio | PEG-PEI:CPP44RPM:siRNA = 20:10:1 |
| Formulation Format | peptide–polymer–siRNA nanoparticles (PPCi) |
| Formulation Components | CPP44RPM + PEG-PEI + siPLK1 |
| Size Nm | 150.00 |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | HepG2 xenograft (BALB/c nude mice) |
| Administration Route | intratumoral injection |
| Output Type | tumor growth inhibition / survival benefit |
| Output Value | >50% tumor volume reduction; prolonged survival |
| Output Units | |
| Output Notes | Sustained tumor retention; significant PLK1 knockdown in tumors |
| Toxicity Notes | No significant systemic toxicity |
| Curation Notes |