Sequence: polypeptide (exact sequence not disclosed)
| Experiment Id | EXP000630 |
|---|---|
| Paper | Systemic siRNA delivery to tumors by cell-penetrating α-helical polypeptide-based metastable nanopar |
| Peptide | PVBLG-8 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | 1 mg siRNA/kg |
| Rna Concentration | 1 mg/kg |
| Mixing Ratio | as above |
| Formulation Format | metastable polymeric nanoparticles (PSPP NPs) |
| Formulation Components | PVBLG-8 + PLG + siRNA |
| Size Nm | 120.00 |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | U-87 MG xenograft nude mice |
| Administration Route | intravenous |
| Output Type | tumor growth inhibition / gene silencing |
| Output Value | significant tumor suppression; strong EGFR knockdown |
| Output Units | |
| Output Notes | Superior to PLL and Lipofectamine 2000 |
| Toxicity Notes | No significant systemic toxicity |
| Curation Notes |