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EXP000651

Paper

Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrating zwitterionic peptide-lipid derivatives (2023)

Peptide

EK-(EK)4-lipid

Sequence: EK(EK)4

RNA

none (uptake model)

All experiment fields

Experiment Id EXP000651
Paper Investigation of enhanced intracellular delivery of nanomaterials modified with novel cell-penetrati
Peptide EK-(EK)4-lipid
Delivery Success Class no
In Vivo Flag no
Uptake Confirmed yes
Label Confidence high
In Vitro Functional Effect no
Endosomal Escape Evidence
Peptide Concentration 6 mol% lipid
Rna Concentration
Mixing Ratio
Formulation Format liposomes
Formulation Components PEGylated liposomes ± CPP-lipid
Size Nm 80.00
Zeta Mv
Model Scope in_vitro
Model Type in vitro
Cell Lines Or Primary Cells A549; MIA Paca-2; Colon-26; NIH3T3
Animal Model
Administration Route
Output Type cellular association
Output Value Enhanced cellular association vs PEGylated control (varies by sequence)
Output Units
Output Notes Flow cytometry and confocal microscopy; no in vivo experiments.
Toxicity Notes No significant cytotoxicity reported.
Curation Notes