Discovery of a new class of cell-penetrating peptides by novel phage display platform (2024)
Sequence: RRRRRRRRR
| Experiment Id | EXP000724 |
|---|---|
| Paper | Discovery of a new class of cell-penetrating peptides by novel phage display platform |
| Peptide | 9R |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | 200–2000 nM |
| Rna Concentration | equimolar |
| Mixing Ratio | |
| Formulation Format | covalent peptide–siRNA conjugate (monomer) |
| Formulation Components | 9R–siRNA conjugate |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HEK293, N2a, SH-SY5Y |
| Animal Model | |
| Administration Route | |
| Output Type | qRT-PCR HPRT mRNA knockdown |
| Output Value | Low or no knockdown compared to NNJA peptides |
| Output Units | |
| Output Notes | Used as classical CPP controls; inferior performance vs NNJA |
| Toxicity Notes | No significant toxicity reported |
| Curation Notes |