Sequence: CKRRMKWKK
| Experiment Id | EXP000735 |
|---|---|
| Paper | Thermal and magnetic dual-responsive liposomes with a cell-penetrating peptide–siRNA conjugate for e |
| Peptide | CPP (penetratin-derived) |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | 1.2 mg/kg siRNA (i.v.) |
| Mixing Ratio | siRNA–CPP conjugate encapsulated in liposomes |
| Formulation Format | Thermal and magnetic dual-responsive liposomes (siRNA-CPPs/TML) |
| Formulation Components | Thermosensitive lipids + Fe3O4 magnetic core + siRNA–CPP conjugate |
| Size Nm | 90.00 |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | MCF-7 xenograft nude mouse model |
| Administration Route | Intravenous injection + magnetic targeting + AC magnetic field hyperthermia |
| Output Type | Tumor growth inhibition and in vivo gene silencing |
| Output Value | Significant tumor growth suppression, c-Myc mRNA/protein knockdown, improved tumor accumulation |
| Output Units | |
| Output Notes | Magnetic + thermal activation essential; free siRNA and CPP–siRNA alone ineffective in vivo |
| Toxicity Notes | No significant body weight loss or acute toxicity reported |
| Curation Notes |