Self-assembled miRNA-switch nanoparticles target denuded regions and prevent restenosis (2021)
Sequence: VLTTGLPALISWIKRKRQQ
| Experiment Id | EXP000738 |
|---|---|
| Paper | Self-assembled miRNA-switch nanoparticles target denuded regions and prevent restenosis |
| Peptide | p5RHH |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | 40 nmol p5RHH |
| Rna Concentration | 7 µg mRNA (per dose) |
| Mixing Ratio | Charge ratio ~+10:1 |
| Formulation Format | Self-assembled peptide–mRNA nanoparticles |
| Formulation Components | p5RHH + therapeutic mRNA |
| Size Nm | 200.00 |
| Zeta Mv | 5.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | C57BL/6J femoral artery wire injury mouse |
| Administration Route | Intravenous (retro-orbital) |
| Output Type | Therapeutic efficacy |
| Output Value | Reduced neointima; vessel reendothelialization |
| Output Units | |
| Output Notes | Selective delivery to denuded endothelium |
| Toxicity Notes | No systemic toxicity |
| Curation Notes |