Sequence: LKHLLHLRKRHLLKLSG
| Experiment Id | EXP000747 |
|---|---|
| Paper | Construction of histidine-containing hydrocarbon stapled cell penetrating peptides for in vitro and |
| Peptide | LKH-stEK |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | 10–100 nM (intradermal) |
| Mixing Ratio | siRNA:peptide 1:50 |
| Formulation Format | Non-covalent peptide–siRNA complexes |
| Formulation Components | LKH-stEK + asiCTGF |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Mouse skin wound healing model |
| Administration Route | Intradermal injection |
| Output Type | In vivo gene silencing |
| Output Value | Significant CTGF knockdown; reduced collagen deposition |
| Output Units | |
| Output Notes | |
| Toxicity Notes | |
| Curation Notes |