Sequence: acetyl-KKUKKUKKUKKUKKUGC(cRGDfC)-NH2
| Experiment Id | EXP000761 |
|---|---|
| Paper | Influence of lysine residue in amphipathic helical peptides on targeted delivery of RNA into cancer |
| Peptide | PV |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | 10–25 nM siRNA; 40 nM miR |
| Mixing Ratio | Peptide:RNA molar ratio 50 |
| Formulation Format | Non-covalent peptide–RNA complexes |
| Formulation Components | PV peptide + RNA cargo |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | A549, U-87 MG, WiDr; NIH3T3 (control) |
| Animal Model | |
| Administration Route | Cell incubation |
| Output Type | Uptake and functional RNA delivery |
| Output Value | Only PI shows strong uptake and luciferase knockdown; others ineffective |
| Output Units | |
| Output Notes | Increasing Lys suppresses uptake; PI is cancer-cell selective via integrin αvβ3 |
| Toxicity Notes | No significant toxicity reported |
| Curation Notes |