Sequence: YGRKKRRQRRR
| Experiment Id | EXP000762 |
|---|---|
| Paper | Matrix metalloproteinase-1 induces cleavage of exogenous alphaB-crystallin transduced by a cell-pene |
| Peptide | TAT |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | CPP–protein fusion |
| Formulation Components | TAT-alphaB-crystallin recombinant fusion protein |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | H9c2 rat cardiac myoblasts |
| Animal Model | |
| Administration Route | Protein incubation |
| Output Type | Protein transduction and cytoprotection |
| Output Value | Efficient intracellular delivery of alphaB-crystallin; increased survival under hypoxia |
| Output Units | |
| Output Notes | Study focuses on intracellular proteolytic cleavage by MMP-1; no nucleic acid delivery |
| Toxicity Notes | |
| Curation Notes |