Structural effects of oligomerization of arginine-rich peptides on cellular uptake and cytotoxicity (2016)
Sequence: CRRRRRRRRCRRRRRRRRRC
| Experiment Id | EXP000778 |
|---|---|
| Paper | Structural effects of oligomerization of arginine-rich peptides on cellular uptake and cytotoxicity |
| Peptide | B-mR9 polyplex |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | Optimized formulation (see paper) |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | Peptide–siRNA polyplex |
| Formulation Components | B-mR9 oligomerized CPP complexed with siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | Cancer cell lines (see paper) |
| Animal Model | |
| Administration Route | Cell incubation |
| Output Type | Cellular uptake and gene silencing |
| Output Value | Efficient uptake and enhanced intracellular activity vs R9 |
| Output Units | |
| Output Notes | Oligomerization improves membrane interaction and intracellular delivery |
| Toxicity Notes | |
| Curation Notes |