Structural effects of oligomerization of arginine-rich peptides on cellular uptake and cytotoxicity (2016)
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| Experiment Id | EXP000779 |
|---|---|
| Paper | Structural effects of oligomerization of arginine-rich peptides on cellular uptake and cytotoxicity |
| Peptide | B-mR9 polyplex |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | As administered in vivo |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | Peptide–siRNA polyplex |
| Formulation Components | B-mR9 oligomerized CPP complexed with siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Tumor-bearing mouse model |
| Administration Route | Intravenous injection |
| Output Type | Tumor accumulation and inhibition |
| Output Value | Outstanding tumor accumulation and significant tumor growth inhibition |
| Output Units | |
| Output Notes | Clear in vivo therapeutic efficacy reported |
| Toxicity Notes | |
| Curation Notes |