Sequence: RKKRRQRRR
| Experiment Id | EXP001298 |
|---|---|
| Paper | Photochemically enhanced delivery of a cell-penetrating peptide nucleic acid conjugate targeting hum |
| Peptide | Tat |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | no |
| Label Confidence | medium |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | PNA–CPP conjugate + photochemical internalization (PCI) |
| Formulation Components | hTERT-PNA-Tat + photosensitizer TPPS2a (0.7 µg/mL, 18 h) then 4 h chase, then blue light 90 s (≈405 nm peak) to rupture endosomal membranes |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | U2-OS (hTERT-negative osteosarcoma) |
| Animal Model | |
| Administration Route | |
| Output Type | negative control |
| Output Value | No specific growth inhibition attributable to hTERT targeting (hTERT-negative line) |
| Output Units | |
| Output Notes | Used 2 µM hTERT-PNA-Tat in PCI schedule; growth inhibition similar to photochemical treatment alone. |
| Toxicity Notes | |
| Curation Notes |