Sequence: CKRRMKWKK
| Experiment Id | EXP001427 |
|---|---|
| Paper | Cell-penetrating peptide-siRNA conjugate loaded YSA-modified nanobubbles for ultrasound triggered si |
| Peptide | Penetratin-derived CPP |
| Delivery Success Class | no |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | 10 mg/kg c-Myc siRNA (as CPP–siRNA conjugate) via tail vein |
| Mixing Ratio | Covalent 1:1 CPP:siRNA via disulfide bond |
| Formulation Format | Free CPP–siRNA conjugate |
| Formulation Components | CPP–siRNA conjugate (disulfide-linked; reducible by cytosolic GSH) (no nanobubble; no targeting; no ultrasound) |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | BALB/c nude mice with MCF-7 xenograft tumors |
| Administration Route | Intravenous (tail vein) |
| Output Type | Tumor growth (relative tumor volume) and tumor c-Myc expression |
| Output Value | |
| Output Units | |
| Output Notes | Only modest tumor inhibition reported compared with CPP–siRNA/YSA-NB (+US); attributed to instability/non-specific distribution. |
| Toxicity Notes | No major acute toxicity reported in body weight monitoring. |
| Curation Notes |