Sequence: YGRRRRRRRRR
| Experiment Id | EXP001480 |
|---|---|
| Paper | Interference of hepatitis C virus replication in cell culture by antisense peptide nucleic acids tar |
| Peptide | Arginine-rich CPP |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | 5 µM |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | covalent CPP–PNA conjugate |
| Formulation Components | Arginine-rich CPP + antisense PNA (SL1) (covalent) |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | R-1 (Huh7-derived HCV subgenomic replicon, genotype 1b) |
| Animal Model | |
| Administration Route | |
| Output Type | HCV genome copy number (qRT-PCR) |
| Output Value | Anti-HCV effect similar to Tat-PNA-SL1 at 48 h |
| Output Units | |
| Output Notes | AR-PNA-SL1 showed a similar reduction in HCV genome copy number compared with Tat-PNA-SL1 in R-1 cells. |
| Toxicity Notes | |
| Curation Notes |