Sequence: GRKKRRQRRRPPQ
| Experiment Id | EXP001484 |
|---|---|
| Paper | Interference of hepatitis C virus replication in cell culture by antisense peptide nucleic acids tar |
| Peptide | Tat48-60 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | (not explicitly stated) |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | covalent CPP–PNA conjugate |
| Formulation Components | HIV-1 Tat48–60 peptide + antisense PNA (SL3-15, 15-mer) (covalent) |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | R-1 (Huh7-derived HCV subgenomic replicon, genotype 1b) |
| Animal Model | |
| Administration Route | |
| Output Type | HCV genome copy number (qRT-PCR) |
| Output Value | Greater antiviral activity than 13-mer SL3 |
| Output Units | |
| Output Notes | In R-1 cells, 15-mer PNA-SL3 showed greater antiviral activity than the 13-mer SL3 PNA. |
| Toxicity Notes | |
| Curation Notes |