Sequence: Stearyl-AGYLLGKLLOOLAAAALOOLLK(εNH-CR6G)
| Experiment Id | EXP001509 |
|---|---|
| Paper | Simultaneous membrane interaction of amphipathic peptide monomers, self-aggregates and cargo complex |
| Peptide | PF14K-CR6G |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | no |
| Label Confidence | medium |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | 100 nM (calculated from MR10 & 10 nM siRNA) |
| Rna Concentration | 10 nM |
| Mixing Ratio | MR10 (peptide:siRNA) |
| Formulation Format | non-covalent peptide/siRNA complex |
| Formulation Components | PF14K-CR6G + anti-Luc siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | U87-Luc glioblastoma cells |
| Animal Model | |
| Administration Route | |
| Output Type | gene knockdown (luciferase assay) |
| Output Value | |
| Output Units | |
| Output Notes | Labeled peptide showed no significant difference vs PF14 in anti-Luc siRNA delivery (Fig. S10). |
| Toxicity Notes | |
| Curation Notes |