Sequence: PFVYLIRFHRFHRFH
| Experiment Id | EXP001645 |
|---|---|
| Paper | Structure-guided design of nucleosome-inspired nanoparticles for overcoming pulmonary barriers in fi |
| Peptide | MN |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | Typically N/P=12 (screening 4–20) |
| Formulation Format | peptide/siRNA complexes (aggregation-prone at high N/P) |
| Formulation Components | MN + siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | U2OS-RFP; A549 |
| Animal Model | |
| Administration Route | |
| Output Type | gene knockdown |
| Output Value | Lead carrier in first-stage screen (strong RFP knockdown); TGF-β1 knockdown in A549 (WB). |
| Output Units | |
| Output Notes | MN identified as P14 (PFVYLIRFHRFHRFH). |
| Toxicity Notes | |
| Curation Notes |