Sequence: PFVYLIRFHRFHRFH
| Experiment Id | EXP001654 |
|---|---|
| Paper | Structure-guided design of nucleosome-inspired nanoparticles for overcoming pulmonary barriers in fi |
| Peptide | MN |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | medium |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | Repeated dosing; N/P typically 20 for MNM NPs (see paper) |
| Formulation Format | intratracheal peptide/siRNA assemblies |
| Formulation Components | MN + siTGF-β1 |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | C57BL/6J pulmonary fibrosis model (bleomycin, incl. 1.5 U/kg and 3 U/kg fast-progressive model) |
| Administration Route | intratracheal |
| Output Type | in vivo therapeutic effect |
| Output Value | Survival improvement and reduced fibrosis; gene expression suppression (qPCR/WB) reported. |
| Output Units | |
| Output Notes | MN–siTGF-β1 complexes showed therapeutic benefit in aggressive PF model (survival improvement). |
| Toxicity Notes | |
| Curation Notes |