FA-R9-FPcas-3 (FMN-17 carrier peptide)
Sequence: FA-(Arg)9-(click-linker)-Ac-DEVD-PABA-mCy (NIR dye)
| Experiment Id | EXP001744 |
|---|---|
| Paper | Renal-targeting peptide-microRNA nanocomplex for near IR imaging and therapy of renal ischemia/reper |
| Peptide | FA-R9-FPcas-3 (FMN-17 carrier peptide) |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | Matched to FMN-17 conditions |
| Rna Concentration | 100 nM miR-NC |
| Mixing Ratio | Matched to FMN-17 (e.g., 20:1) |
| Formulation Format | Self-assembled peptide/miRNA nanocomplex (FMN) |
| Formulation Components | FA-R9-FPcas-3 peptide + miR-NC (self-assembled FMN-NC) |
| Size Nm | 200.00 |
| Zeta Mv | 5.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HK-2 (H/R model) |
| Animal Model | |
| Administration Route | |
| Output Type | in vitro negative control |
| Output Value | Does not reduce H/R-induced apoptosis or cleaved caspase-3 compared with FMN-17; higher fluorescence turn-on signal consistent with higher caspase-3 activity. |
| Output Units | |
| Output Notes | Used as control nanocomplex (FMN-NC) in apoptosis/ROS/NAG/TUNEL and imaging readouts. |
| Toxicity Notes | |
| Curation Notes |