Sequence: FCIGRLCG
| Experiment Id | EXP001843 |
|---|---|
| Paper | Development of an Efficient Transdermal Delivery System of Small Interfering RNA Using Functional Pe |
| Peptide | AT1002 analog (AT-1002) |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | no |
| Label Confidence | medium |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | AT1002:siRNA weight ratio = 80:1 (prepared 30 min at 4°C) |
| Formulation Format | AT1002 + siRNA mixing solution (non-condensing enhancer) |
| Formulation Components | AT1002 mixed with siRelA; evaluated for RNaseA protection (10 ng RNaseA, 37°C, up to 10 h) |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | |
| Animal Model | |
| Administration Route | |
| Output Type | siRNA stability against RNaseA |
| Output Value | AT1002 improves siRNA stability vs naked (partial protection) |
| Output Units | |
| Output Notes | Relative remaining siRNA quantified by fluorescence vs time. |
| Toxicity Notes | |
| Curation Notes |