Sequence: NTCTWLKYHS
| Experiment Id | EXP001955 |
|---|---|
| Paper | Identification of a novel cell-penetrating peptide targeting human glioblastoma cell lines as a canc |
| Peptide | Peptide1 (GBM-homing CPP) |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | Peptide alone or peptide–cargo fusion (no RNA payload) |
| Formulation Components | FITC-labeled peptides for uptake assays; p16 MIS fusion peptides for functional cargo delivery (apoptosis/pRB phosphorylation). |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | U87MG and U118MG (glioblastoma); other lines for selectivity panel (HeLa, HepG2, A549, PANC-1, etc.) |
| Animal Model | |
| Administration Route | |
| Output Type | Cellular uptake/selectivity (confocal microscopy + quantification) |
| Output Value | High selective uptake into U87MG vs multiple other cell lines; also permeates U118MG. |
| Output Units | |
| Output Notes | Identified via mRNA display screening from random peptide library; compared to R9 (nona-arginine) nonselective CPP. |
| Toxicity Notes | |
| Curation Notes |