Trends in the Binding of Cell Penetrating Peptides to siRNA: A Molecular Docking Study (2017)
Sequence: RQIKIWFQNRRMKWKK
| Experiment Id | EXP002035 |
|---|---|
| Paper | Trends in the Binding of Cell Penetrating Peptides to siRNA: A Molecular Docking Study |
| Peptide | Penetratin |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | Variable CPP:siRNA ratios (1–30) simulated |
| Formulation Format | Noncovalent CPP–siRNA complex (in silico docking) |
| Formulation Components | CPP + siRNA (computational models only) |
| Size Nm | 10.00 |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in silico |
| Cell Lines Or Primary Cells | |
| Animal Model | |
| Administration Route | |
| Output Type | binding energy scores; binding orientation trends |
| Output Value | Relative ClusPro docking scores (no experimental validation) |
| Output Units | |
| Output Notes | Purely computational molecular docking and MD; no uptake, no RNAi assays |
| Toxicity Notes | |
| Curation Notes |