Sequence: YGRKKRRQRRR-GGG-CNGRC
| Experiment Id | EXP002053 |
|---|---|
| Paper | Tumor pH-functionalized and charge-tunable nanoparticles for the nucleus/cytoplasm-directed delivery |
| Peptide | T-peptide (TAT–NGR) |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | 100 nM (in vitro) |
| Mixing Ratio | |
| Formulation Format | SLN-T/miR-320 |
| Formulation Components | Solid lipid nanoparticle + T-peptide + PGA–PEG |
| Size Nm | 192.30 |
| Zeta Mv | -43.50 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | SAS (human tongue squamous carcinoma) |
| Animal Model | |
| Administration Route | |
| Output Type | gene knockdown / pathway modulation |
| Output Value | Reduced proliferation, EMT, and apoptosis induction |
| Output Units | |
| Output Notes | Functional miRNA delivery in vitro |
| Toxicity Notes | Low toxicity to NOK cells |
| Curation Notes |