Sequence: YGRKKRRQRRR-GGG-CNGRC
| Experiment Id | EXP002054 |
|---|---|
| Paper | Tumor pH-functionalized and charge-tunable nanoparticles for the nucleus/cytoplasm-directed delivery |
| Peptide | T-peptide (TAT–NGR) |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | 1.25 mg/kg (in vivo) |
| Mixing Ratio | |
| Formulation Format | PGA-SLN-T/miR-320 + PGA-Lip-TR/Oxa |
| Formulation Components | Dual nanoparticle system |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | SAS xenograft nude mouse |
| Administration Route | intravenous (tail vein) |
| Output Type | tumor growth inhibition |
| Output Value | Significant tumor regression and IVIS signal reduction |
| Output Units | |
| Output Notes | Robust antitumor efficacy |
| Toxicity Notes | Reduced systemic toxicity |
| Curation Notes |