Sequence: RRRRRRRRRK
| Experiment Id | EXP002055 |
|---|---|
| Paper | Tumor pH-functionalized and charge-tunable nanoparticles for the nucleus/cytoplasm-directed delivery |
| Peptide | R-peptide (NLS) |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | Lip-TR/Oxa |
| Formulation Components | Liposome + T-peptide + R-peptide + PGA–PEG |
| Size Nm | 143.10 |
| Zeta Mv | -37.80 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | SAS (human tongue squamous carcinoma) |
| Animal Model | |
| Administration Route | |
| Output Type | nuclear drug delivery |
| Output Value | Enhanced nuclear localization of oxaliplatin |
| Output Units | |
| Output Notes | Contributes to in vivo efficacy via nuclear targeting of oxaliplatin; not an RNA delivery system |
| Toxicity Notes | Reduced toxicity vs free Oxa |
| Curation Notes |