Sequence: RRRRRRRRRK
| Experiment Id | EXP002056 |
|---|---|
| Paper | Tumor pH-functionalized and charge-tunable nanoparticles for the nucleus/cytoplasm-directed delivery |
| Peptide | R-peptide (NLS) |
| Delivery Success Class | no |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | PGA-Lip-TR/Oxa + PGA-SLN-T/miR-320 |
| Formulation Components | Dual nanoparticle system |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | SAS xenograft nude mouse |
| Administration Route | intravenous (tail vein) |
| Output Type | tumor growth inhibition |
| Output Value | Synergistic tumor regression with miR-320 system |
| Output Units | |
| Output Notes | Contributes to in vivo efficacy via nuclear targeting of oxaliplatin; not an RNA delivery system |
| Toxicity Notes | Reduced systemic toxicity |
| Curation Notes |