Sequence: YGRKKRRQRRR
| Experiment Id | EXP002059 |
|---|---|
| Paper | A pH-Responsive Nanoplatform Based on Fluorescent Conjugated Polymer Dots for Imaging-Guided Multith |
| Peptide | TAT peptide |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | siRNA-CPNP@CaP |
| Formulation Components | Conjugated polymer dots + TAT + CaP + AS1411 aptamer |
| Size Nm | 140.00 |
| Zeta Mv | -11.70 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | MCF-7 breast cancer cells |
| Animal Model | |
| Administration Route | |
| Output Type | gene knockdown / apoptosis |
| Output Value | EGFR protein downregulation; apoptosis induction |
| Output Units | |
| Output Notes | Clear siRNA-mediated gene silencing in vitro |
| Toxicity Notes | Low cytotoxicity of carrier |
| Curation Notes |