Sequence: YGRKKRRQRRR
| Experiment Id | EXP002060 |
|---|---|
| Paper | A pH-Responsive Nanoplatform Based on Fluorescent Conjugated Polymer Dots for Imaging-Guided Multith |
| Peptide | TAT peptide |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | |
| Formulation Format | siRNA-CPNP@CaP-HCPT |
| Formulation Components | Conjugated polymer dots + TAT + CaP + AS1411 aptamer + HCPT |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | MCF-7 xenograft nude mouse |
| Administration Route | intravenous / peritumoral |
| Output Type | tumor growth inhibition |
| Output Value | Significant tumor volume and weight reduction |
| Output Units | |
| Output Notes | Functional in vivo siRNA delivery with combination therapy |
| Toxicity Notes | No major organ toxicity observed |
| Curation Notes |