Sequence: CRRRRRHHHHHHHRRRRC
| Experiment Id | EXP002071 |
|---|---|
| Paper | Surface-Engineered Mucus Penetrating Nucleic Acid Delivery Systems with Cell Penetrating Peptides fo |
| Peptide | CRHC-2 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | 40 ng/µL DNA; 20 nM siRNA |
| Mixing Ratio | N/P = 10 |
| Formulation Format | Peptide–RNA nanocomplex with polymer coating |
| Formulation Components | CRHC-2 + nucleic acid core; CS-A–mannitol coating |
| Size Nm | 200.00 |
| Zeta Mv | 20.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | A549, BEAS-2B |
| Animal Model | |
| Administration Route | |
| Output Type | reporter expression |
| Output Value | Enhanced GFP expression vs uncoated complexes |
| Output Units | |
| Output Notes | Improved mucus penetration and transfection with CS-A–mannitol |
| Toxicity Notes | Low cytotoxicity |
| Curation Notes |