Design and Evaluation of Endosomolytic Biocompatible Peptides as Carriers for siRNA Delivery (2015)
Sequence: GLWHLLLHLWRRLLRLLR
| Experiment Id | EXP002087 |
|---|---|
| Paper | Design and Evaluation of Endosomolytic Biocompatible Peptides as Carriers for siRNA Delivery |
| Peptide | C6M6 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | 0.16 mg/kg |
| Mixing Ratio | 60:1 |
| Formulation Format | noncovalent peptide/siRNA complex |
| Formulation Components | peptide + siRNA |
| Size Nm | 100.00 |
| Zeta Mv | 30.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | A549 xenograft in BALB/c nude mice |
| Administration Route | intratumoral |
| Output Type | tumor growth inhibition |
| Output Value | ~54% tumor inhibition |
| Output Units | |
| Output Notes | Reduced Bcl-2 protein expression |
| Toxicity Notes | No weight loss or immune activation |
| Curation Notes |