Sequence: FFLIPKGMIASHLLAYFFTELN
| Experiment Id | EXP002096 |
|---|---|
| Paper | Hexokinase II-Derived Cell-Penetrating Peptide Mediates Delivery of MicroRNA Mimic for Cancer-Select |
| Peptide | PAS-pHK |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | 10–150 µM |
| Rna Concentration | equimolar (conjugated) |
| Mixing Ratio | covalent conjugate |
| Formulation Format | covalent peptide–miRNA conjugate |
| Formulation Components | CPP–miRNA conjugate |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | MCF-7; MCF-10A; HEK-293 |
| Animal Model | |
| Administration Route | |
| Output Type | cell viability / apoptosis |
| Output Value | Cancer-selective cytotoxicity |
| Output Units | |
| Output Notes | Only PAS-pHK variants showed efficient cytosolic delivery and miRNA-mediated effects |
| Toxicity Notes | Selective toxicity to cancer cells only |
| Curation Notes |