Sequence: WEARLARALARALARHLARALARALRACEA
| Experiment Id | EXP002105 |
|---|---|
| Paper | The osteogenic and angiogenic potential of microRNA-26a delivered via a non-viral delivery peptide f |
| Peptide | RALA |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | embedded in hydrogel |
| Rna Concentration | 5 µg per defect |
| Mixing Ratio | N:P = 8 |
| Formulation Format | peptide–miRNA nanoparticles in thermoresponsive hydrogel |
| Formulation Components | RALA + miR-26a + Cs-g-PNIPAAm hydrogel |
| Size Nm | 74.00 |
| Zeta Mv | 21.00 |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | Rat critical-sized calvarial defect |
| Administration Route | local injection |
| Output Type | bone regeneration |
| Output Value | Increased bone volume, mineral density, vascularisation |
| Output Units | |
| Output Notes | Enhanced defect bridging and mechanical properties at 8 weeks |
| Toxicity Notes | No adverse events |
| Curation Notes |