Sequence: CTRPTRSKC
| Experiment Id | EXP002113 |
|---|---|
| Paper | Discovery of peptides for ligand-mediated delivery of mRNA lipid nanoparticles to cystic fibrosis lu |
| Peptide | Peptide B |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | N/P = 6 |
| Formulation Format | peptide-lipid functionalized LNP |
| Formulation Components | SM-102/DSPC/Cholesterol/DMG-PEG + peptide-lipid |
| Size Nm | 80.00 |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | CF primary human bronchial epithelial cells (ALI) |
| Animal Model | |
| Administration Route | |
| Output Type | reporter expression |
| Output Value | enhanced luciferase vs control (highest for Peptide C) |
| Output Units | |
| Output Notes | Functional mRNA delivery demonstrated in vitro |
| Toxicity Notes | No significant toxicity in vitro or in vivo |
| Curation Notes |