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EXP002126

Paper

Supplementation With Cell-Penetrating Peptide-Conjugated Estrogen-Related Receptor β Improves the Formation of the Inner Cell Mass and the Development of Vitrified/Warmed Mouse Embryos (2016)

Peptide

CPP-ESRRB (7R-ESRRB)

Sequence: RRRRRRR-ESRRB

RNA

mRNA (endogenous regulation)

All experiment fields

Experiment Id EXP002126
Paper Supplementation With Cell-Penetrating Peptide-Conjugated Estrogen-Related Receptor β Improves the Fo
Peptide CPP-ESRRB (7R-ESRRB)
Delivery Success Class yes
In Vivo Flag yes
Uptake Confirmed yes
Label Confidence high
In Vitro Functional Effect
Endosomal Escape Evidence
Peptide Concentration 2 mg/mL
Rna Concentration
Mixing Ratio protein added to culture medium
Formulation Format CPP–protein delivery
Formulation Components 7R CPP + ESRRB recombinant protein
Size Nm
Zeta Mv
Model Scope in_vivo
Model Type in vivo
Cell Lines Or Primary Cells
Animal Model Mouse (embryo transfer into pseudopregnant females)
Administration Route embryo transfer
Output Type implantation / embryonic development
Output Value Higher implantation rate and full-term development
Output Units
Output Notes CPP-ESRRB-treated embryos showed improved implantation and healthy offspring
Toxicity Notes No developmental toxicity; healthy pups born
Curation Notes