Sequence: KFFKFFKFFK
| Experiment Id | EXP002137 |
|---|---|
| Paper | Evaluating delivery of peptide nucleic acids to Gram-negative bacteria using membrane-active peptide |
| Peptide | (KFF)3K–S–S–PNAmm |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | 0.5–8 µM |
| Rna Concentration | |
| Mixing Ratio | covalent conjugate |
| Formulation Format | peptide–PNA conjugate |
| Formulation Components | membrane-active peptide + PNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | E. coli; S. Typhimurium |
| Animal Model | |
| Administration Route | |
| Output Type | bacterial growth inhibition (MIC) |
| Output Value | MIC 1–8 µM depending on conjugate |
| Output Units | |
| Output Notes | Antisense antibacterial activity; no eukaryotic testing |
| Toxicity Notes | Not evaluated in mammalian systems |
| Curation Notes |