Multiscale modeling of the cellular uptake of C6 peptide-siRNA complexes (2022)
Sequence: RLLRILWHLWRRLWRLLR
| Experiment Id | EXP002157 |
|---|---|
| Paper | Multiscale modeling of the cellular uptake of C6 peptide-siRNA complexes |
| Peptide | C6M2 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | CPP:siRNA up to 30:1 (modeled) |
| Formulation Format | CPP/siRNA complex (in silico) |
| Formulation Components | C6M2 peptide + siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in silico |
| Cell Lines Or Primary Cells | |
| Animal Model | |
| Administration Route | |
| Output Type | binding free energy / translocation free energy |
| Output Value | favorable binding and membrane adsorption (MD simulations) |
| Output Units | |
| Output Notes | Purely computational multiscale MD and docking study; no experimental uptake or functional assays performed. Experimental efficacy referenced only from prior literature (Jafari et al.). |
| Toxicity Notes | |
| Curation Notes |