Enhanced Intracellular Delivery by Twisted CC-Loop Conformation in Cyclic Cell-Penetrating Peptides (2025)
Sequence: SVS1-derived 18mer (linear)
| Experiment Id | EXP002182 |
|---|---|
| Paper | Enhanced Intracellular Delivery by Twisted CC-Loop Conformation in Cyclic Cell-Penetrating Peptides |
| Peptide | Y2-17 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | 10–100 µM |
| Rna Concentration | 100 nM (siRNA) |
| Mixing Ratio | simple electrostatic mixing |
| Formulation Format | CPP/siRNA complex |
| Formulation Components | Y2-17 |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | A549, HeLa |
| Animal Model | |
| Administration Route | |
| Output Type | siRNA knockdown / cargo delivery |
| Output Value | Y2-13-OX ≈ Lipofectamine; others weaker |
| Output Units | |
| Output Notes | siRNA knockdown, ssDNA, GFP, and plasmid delivery shown; Y2-13-OX most efficient |
| Toxicity Notes | Low toxicity except Y2-17 variants |
| Curation Notes |