Enhanced Intracellular Delivery by Twisted CC-Loop Conformation in Cyclic Cell-Penetrating Peptides (2025)
Sequence: SVS1-derived 18mer
| Experiment Id | EXP002184 |
|---|---|
| Paper | Enhanced Intracellular Delivery by Twisted CC-Loop Conformation in Cyclic Cell-Penetrating Peptides |
| Peptide | Y2-13-OX |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | 20 mg/kg |
| Rna Concentration | 1.2 mg/kg |
| Mixing Ratio | simple electrostatic mixing |
| Formulation Format | CPP/siRNA complex |
| Formulation Components | Y2-13-OX + siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | BALB/c mice; HCT116 xenograft |
| Administration Route | local intratumoral |
| Output Type | tumor siRNA delivery (confocal imaging) |
| Output Value | strong Cy5 signal in tumor tissue |
| Output Units | |
| Output Notes | Only Y2-13-OX tested in vivo; enhanced tumor penetration vs siRNA alone |
| Toxicity Notes | No acute toxicity reported |
| Curation Notes |