Sequence: TVSALK
| Experiment Id | EXP002195 |
|---|---|
| Paper | Selective peptide–guided transcytosis enhances extracellular vesicle–mediated siRNA delivery across |
| Peptide | CPP.16 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | no |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | 900 pmol (donor cell loading) |
| Mixing Ratio | endogenous loading via donor cell transfection |
| Formulation Format | peptide-modified small extracellular vesicle |
| Formulation Components | CPP.16-sEV |
| Size Nm | 120.00 |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | hCMEC/D3 BBB model; U87MG |
| Animal Model | |
| Administration Route | |
| Output Type | BBB transcytosis and gene knockdown |
| Output Value | RVG > CPP.16 |
| Output Units | |
| Output Notes | Peptides do not increase endothelial uptake; RVG enhances transcytosis and delivery to basal cells |
| Toxicity Notes | No BBB disruption |
| Curation Notes |