Sequence: YTIWMPENPRPGTPCDIFTNSRGKRASNG
| Experiment Id | EXP002196 |
|---|---|
| Paper | Selective peptide–guided transcytosis enhances extracellular vesicle–mediated siRNA delivery across |
| Peptide | RVG |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | 20 µg sEV protein |
| Rna Concentration | loaded via donor cells |
| Mixing Ratio | endogenous loading via donor cell transfection |
| Formulation Format | peptide-modified small extracellular vesicle |
| Formulation Components | RVG-sEV |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | C57BL/6J mice |
| Administration Route | intravenous |
| Output Type | brain delivery and gene knockdown |
| Output Value | RVG superior brain parenchyma delivery |
| Output Units | |
| Output Notes | RVG-sEVs cross BBB and silence EGFR in neurons and astrocytes |
| Toxicity Notes | No systemic toxicity reported |
| Curation Notes |