Sequence: HEHEHGFLGRVRVLRGDKW
| Experiment Id | EXP002232 |
|---|---|
| Paper | Systematic design of DMBT1-derived peptides correlating physicochemical properties and sequence moti |
| Peptide | HE25 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | no |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | |
| Peptide Concentration | |
| Rna Concentration | |
| Mixing Ratio | optimized peptide:siRNA molar ratio |
| Formulation Format | CPP/siRNA complex |
| Formulation Components | HE25 |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | A375 xenograft mouse |
| Administration Route | intravenous |
| Output Type | tumor growth suppression |
| Output Value | significant |
| Output Units | |
| Output Notes | BRAFV600E silencing; Ki-67 reduction |
| Toxicity Notes | no weight loss or systemic toxicity |
| Curation Notes |