Sequence: Arachidyl-HHHHYHHGOaILLKALKALAKAIL-NH2
| Experiment Id | EXP002265 |
|---|---|
| Paper | NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery in |
| Peptide | NF70 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | CPP:miRNA MR 17:1–28:1 |
| Rna Concentration | 30–100 nM |
| Mixing Ratio | CPP:miRNA 17:1 or 28:1 |
| Formulation Format | CPP–miRNA nanocomplex |
| Formulation Components | NF70 + miR-146a |
| Size Nm | 15.00 |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | primary keratinocytes; monocyte-derived dendritic cells |
| Animal Model | |
| Administration Route | cell incubation |
| Output Type | target gene suppression |
| Output Value | ↓ IRAK1, CARD10, IL-6, CXCL8 (CPP-dependent) |
| Output Units | |
| Output Notes | NF-type CPPs outperform PF/MGPE in DCs |
| Toxicity Notes | no cytotoxicity; no DC activation |
| Curation Notes |