Sequence: Stearyl-HHYHHGOaILLKALKALAKAIL-NH2
| Experiment Id | EXP002270 |
|---|---|
| Paper | NickFect type of cell-penetrating peptides present enhanced efficiency for microRNA-146a delivery in |
| Peptide | NF71 |
| Delivery Success Class | yes |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | 60 pmol per ear |
| Rna Concentration | 60 pmol per ear |
| Mixing Ratio | CPP:miRNA 28:1 |
| Formulation Format | CPP–miRNA nanocomplex |
| Formulation Components | NF71 + miR-146a |
| Size Nm | 50.00 |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | C57BL/6 mouse ICD model |
| Administration Route | subcutaneous ear injection |
| Output Type | inflammation suppression |
| Output Value | ↓ ear swelling; ↓ IL-6, IL-1β, IL-33, TNF-α |
| Output Units | |
| Output Notes | functional miRNA delivery in vivo |
| Toxicity Notes | no inflammation without PMA |
| Curation Notes |