Sequence: CGRKKRRQRRR; KACDCRGDCFCG
| Experiment Id | EXP002288 |
|---|---|
| Paper | Traceable Multifunctional Micellar Nanocarriers for Cancer-Targeted Co-delivery of MDR-1 siRNA and D |
| Peptide | TAT + RGD4C |
| Delivery Success Class | no |
| In Vivo Flag | yes |
| Uptake Confirmed | yes |
| Label Confidence | medium |
| In Vitro Functional Effect | |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | siRNA 100 nmol/kg |
| Rna Concentration | 100 nmol/kg |
| Mixing Ratio | micellar formulation |
| Formulation Format | polymeric micelle (traceable) |
| Formulation Components | RGD/TAT micelle + siRNA + DOX |
| Size Nm | 100.00 |
| Zeta Mv | |
| Model Scope | in_vivo |
| Model Type | in vivo |
| Cell Lines Or Primary Cells | |
| Animal Model | athymic nude mouse xenograft (MDA-MB-435/LCC6 MDR) |
| Administration Route | intravenous injection |
| Output Type | tumor targeting and biodistribution |
| Output Value | tumor accumulation of siRNA and micelles |
| Output Units | |
| Output Notes | NIRF imaging confirms tumor delivery; therapeutic efficacy suggested |
| Toxicity Notes | no acute toxicity reported |
| Curation Notes |