Cell-penetrating Peptide for Enhanced Delivery of Nucleic Acids and Drugs to Ocular Tissues (2008)
Sequence: GGG(ARKKAAKA)4
| Experiment Id | EXP002300 |
|---|---|
| Paper | Cell-penetrating Peptide for Enhanced Delivery of Nucleic Acids and Drugs to Ocular Tissues |
| Peptide | POD |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | |
| Peptide Concentration | nmol range |
| Rna Concentration | pmol range |
| Mixing Ratio | electrostatic complexation |
| Formulation Format | CPP–RNA complex |
| Formulation Components | POD + siRNA |
| Size Nm | |
| Zeta Mv | |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | HER 911 cells |
| Animal Model | |
| Administration Route | cell culture |
| Output Type | gene knockdown |
| Output Value | >50% GFP knockdown |
| Output Units | |
| Output Notes | Functional siRNA delivery in vitro |
| Toxicity Notes | No significant toxicity reported |
| Curation Notes |