Sequence: (cholesterol)2-Lys-(Gly)2-(Arg)9
| Experiment Id | EXP002303 |
|---|---|
| Paper | Reshaping Prostate Tumor Microenvironment To Suppress Metastasis via Cancer-Associated Fibroblast In |
| Peptide | Chol-R9 |
| Delivery Success Class | no |
| In Vivo Flag | no |
| Uptake Confirmed | yes |
| Label Confidence | high |
| In Vitro Functional Effect | yes |
| Endosomal Escape Evidence | yes |
| Peptide Concentration | 25–100 µg/mL (PNP) |
| Rna Concentration | 100 nM |
| Mixing Ratio | electrostatic assembly |
| Formulation Format | peptide nanoparticle |
| Formulation Components | Chol-R9 PNP + siRNA + anti-FAPα mAb |
| Size Nm | 85.00 |
| Zeta Mv | -13.00 |
| Model Scope | in_vitro |
| Model Type | in vitro |
| Cell Lines Or Primary Cells | CAFs (primary) |
| Animal Model | |
| Administration Route | cell culture |
| Output Type | gene silencing |
| Output Value | ~89% CXCL12 knockdown |
| Output Units | |
| Output Notes | qRT-PCR, Western blot, ELISA |
| Toxicity Notes | No cytotoxicity observed |
| Curation Notes |